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Cl-amidine hydrochloride
CAS No. 1373232-26-8
Cl-amidine hydrochloride ( —— )
产品货号. M23526 CAS No. 1373232-26-8
Cl-amidine Hydrochloride 是一种口服有效的肽基精氨酸脱氨酶 (PAD) 抑制剂（对于 PAD4，IC50：5.9 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥786 | 有现货 |
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| 10MG | ￥1401 | 有现货 |
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| 25MG | ￥2827 | 有现货 |
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| 50MG | ￥4577 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Cl-amidine hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Cl-amidine Hydrochloride 是一种口服有效的肽基精氨酸脱氨酶 (PAD) 抑制剂（对于 PAD4，IC50：5.9 μM）。
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产品描述Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
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体外实验Apoptosis Analysis.Cell Line:TK6 lymphoblastoid cells and HT29 colon cancer cells. Concentration:0, 5, 10, 15, 20, 25, 50 μg/mL.Incubation Time:24 h.Result:Induced apoptosis dose-dependently.
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体内实验Animal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis).Dosage:75 mg/kg.Administration:IP once daily.Result:Suppressed PAD activity, protein citrullination, and PAD levels in the colon in vivo.Animal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis). Dosage:5, 25, 75 mg/kg.Administration:Oral gavage once daily.Result:Led to significant reductions in the histology scores.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis|MicroRNA|PAD4
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研究领域——
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适应症——
化学信息
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CAS Number1373232-26-8
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分子量347.24
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分子式C14H20Cl2N4O2
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纯度>98% (HPLC)
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溶解度H2O:50 mg/mL (143.99 mM; Need ultrasonic);DMSO:19.23 mg/mL (55.38 mM; Need ultrasonic)
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SMILESO=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Yuan Luo, et al. Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization. Biochemistry. 2006 Oct 3; 45(39): 11727–11736.
